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pentobarbital will lower the level or effect of midostaurin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Solid CYP3A4 inducers may perhaps lessen midostaurin concentrations leading to lowered efficacy.pentobarbital will decrease the extent or result of celecoxib by impacting hepatic enzyme CYP2C9/te